Metformin

Sounds like 'met-FOR-min'

Easy-to-read medicine information about metformin – what it is, how to take it safely and possible side effects.

Type of medicine Also called
  • Medicine to treat type 2 diabetes
  • Metformin 
  • Metchek®

What is metformin?

Metformin is a tablet used to treat type 2 diabetes. It can be used alone or with other medicines, including insulin, to treat diabetes and pre-diabetes, along with good nutrition and regular exercise.

Metformin lowers your blood glucose levels by improving the way your body responds to insulin. Insulin is the hormone that controls the level of glucose in your blood.

Metformin works by:

  • reducing the amount of glucose your liver releases into your blood
  • allowing glucose to move out of your blood and into your cells.

Metformin doesn’t cause weight gain and may help with weight loss; therefore, it is commonly prescribed for overweight people with type 2 diabetes or ‘pre-diabetes’ along with good nutrition and regular exercise.  

Metformin may be used to treat gestational diabetes (diabetes that develops during pregnancy). Read more about taking metformin for gestational diabetes (Māori and Samoan).     

Metformin is also used to treat polycystic ovarian syndrome.

Note: Metformin is also available in combination with vildagliptin, called Galvumet

Dose

  • In New Zealand metformin is available as tablets (500 mg and 850 mg). 
  • The usual starting dose for adults with diabetes is 500 mg 1–2 times daily. Depending on your blood glucose levels, your doctor may increase your dose slowly over a few weeks. This allows your body to get used to the medicine and reduces side effects. 
  • The maximum dose is 3 grams daily (in divided doses) but for some people, such as older adults or people with kidney problems, the maximum daily dose should be lower.
  • Each day's tablets are usually divided into two doses (breakfast and dinner), or three doses (breakfast, lunch and dinner).
  • You may be asked to record your blood glucose levels over this time so your doctor can see how well the metformin is working.
  • Always take your metformin exactly as your doctor has told you. The pharmacy label on your medicine will tell you how much metformin to take, how often to take it and any special instructions. Ask your pharmacist if you have any questions relating to your medication.
  • Treatment for diabetes is usually lifelong. Keep taking metformin every day to control your diabetes. Speak to your doctor, nurse or pharmacist before stopping.

My dose is:

Date Breakfast Lunch Dinner
       
       
       
       
       
Notes:


How to take metformin

  • Always take metformin with food – during a meal or just after a snack.
  • Take metformin at the same times each day.
  • Do not skip meals while taking metformin.
  • Limit or avoid alcohol while taking metformin. It affects the control of your blood glucose and increases your chance of side effects.
  • If you forget to take your dose, take it (with food) as soon as you remember. But, if it is nearly time for your next dose, just take the next dose at the right time. Do not take double the dose.
  • If your tablets look different to your last supply, ask your doctor or pharmacist for advice.

Precautions – before taking metformin

  • Do you have problems with your kidneys, liver or heart?
  • Are you about to have surgery?
  • Are you taking any other medicines? This includes any medicines you buy without a prescription, such as herbal and complementary medicines.

If so, it’s important that you tell your doctor or pharmacist before you start metformin. Sometimes a medicine isn’t suitable for a person with certain conditions, or it can only be used with extra care.

Diabetes and long-term metformin can both cause low levels of vitamin B12. You may need to have a blood test to check vitamin B12 if you have symptoms of anaemia (fatigue, dizziness, mouth ulcers), and may need to take a supplement for this. 

Possible side effects

Like all medicines, metformin can cause side effects, although not everyone gets them. Often side effects improve as your body gets used to the new medicine.

Low blood glucose (hypoglycaemia)

Sometimes (very rarely) metformin may lower your blood glucose too much. This is called hypoglycaemia. This is most likely to occur if you delay or miss a meal or snack, drink alcohol, exercise more than usual or can't eat because of nausea or vomiting. 

Hypoglycaemia can occur if you are also taking other medicines for diabetes. Hypoglycaemia may cause you to feel weak, faint, dizzy or irritable. You may get a headache, tremor (shakes) or blurred vision. If this happens, drink something sweet such as a small glass of sweetened soft drink or fruit juice, or eat something sweet like lollies. Follow this up with a snack such as a sandwich. Tell your doctor or nurse if this happens.

Read more about hypoglycaemia and diabetes sick day plan.

Lactic acidosis

Metformin and other medicines for diabetes can very rarely cause a condition called lactic acidosis. You are at highest risk if you have kidney problems, a severe infection, dehydration or heart failure. To avoid this, your doctor will monitor how well your kidneys are working and adjust your metformin dose accordingly. Also, your doctor may take you off metformin for a short time if you become dehydrated or experience severe diarrhoea, have a severe infection or are undergoing surgery or having an x-ray where a dye is needed. 

Contact your doctor immediately if you are being sick (vomiting) or feel very unwell, have muscle cramps or if you become unusually tired, or if you feel short of breath and your breathing becomes faster than normal – these are the signs of lactic acidosis.

Other side effects

Side effects What should I do?

  • Feeling sick (nausea) 
  • Diarrhoea
  • Stomach upset and bloating

  • Take your metformin with food.
  • These are quite common when you first start taking metformin and usually go away with time.
  • Tell your doctor or pharmacist if troublesome.
  • Changes in taste 
  • Let your doctor know
  • Tiredness, dizziness, mouth ulcers
  • Let your doctor know
  • Drowsiness, stomach cramps, vomiting, muscle pain
  • Let your doctor know or call Healthline 0800 611 116

Interactions

Metformin may interact with a number of medications and herbal supplements, so check with your doctor or pharmacist before starting metformin or before starting any new medicines.

Learn more

Medsafe Consumer Information Sheet: Metformin 
New Zealand Formulary Patient Information: Metformin

Reference

  1. Metformin New Zealand Formulary
  2. Metformin - renal Impairment and risk of lactic acidosis Medsafe 2015
  3. Metformin safe prescribing SafeRx, Waitemata DHB 
Credits: Sandra Ponen, Pharmacist. Reviewed By: Angela Lambie, Pharmacist, Auckland Last reviewed: 24 Jan 2019