Urea cream

Easy-to-read medicine information about urea cream – what is it, and how to use it safely. Urea cream is an example of an emollient (moisturiser).

Type of medicineAlso called
  • Emollient
  • Humectant



  • healthE urea cream®
  • Urea cream®
  • AquaCare HP®
  • Nutraplus® 
  • Eulactol® 

What is urea cream?

  • Urea cream is a non-greasy emollient or moisturiser, used to treat dry skin conditions such as eczema.  
  • When applied to the skin, urea increases the water holding capacity of the skin, thus increasing the hydration or moisture in the skin. In this way it helps to reduce dryness. The moisturising base that the urea is mixed in also provides a layer of oil on the surface of the skin, which helps prevent water from evaporating from the skin surface. Both actions soothe and soften the skin. Read more about emollients and moisturisers.
  • Urea cream is available in different strengths. Urea 10% cream is commonly used  to moisturize moderately dry skin. Urea 25% is used for excessively dry skin or areas of thick skin such as the heels of the foot.         

How to use urea cream

  • Wash your hands before applying urea cream.
  • Apply generous amounts of urea cream on the skin several (at least 2 to 3) times a day or as required.
  • It is best to apply urea cream immediately after washing, bathing or showering, while the skin is still damp.
  • Apply urea cream in a downward motion, in the direction of hair growth and gently massage into your skin. Avoid rubbing.
  • Do not put your hands into the pot, tub or jar of cream when removing for use. This will contaminate the cream. Instead, use a clean spoon or spatula to scoop out the required amount of cream and place onto a clean plate or paper towel. Some people put the cream in a pump bottle to reduce contamination.
  • Do not apply urea cream on weeping or broken (cracked or bleeding) skin or on any area that is infected or oozing. 

Possible side effects

Like all medicines, urea cream can cause unwanted side effects, although not everyone gets them. Often unwanted side effects improve as your body gets used to the new medicine.

Side effectsWhat should I do?
  • Signs of sensitivity or an allergic reaction such as red, itchy skin. This may be confused with a flare up of the eczema or dermatitis
  • Tell your doctor  

Learn more

Emollients and moisturisers Dermnet NZ
Urea Dermnet NZ 
Emollients for eczema Patient Info, UK
Emollient and barrier preparations NZ Formulary

Credits: Sandra Ponen, Pharmacist.