Sounds like 'METH-il-pred-NIS-oh-lone'

Easy-to-read medicine information about methylprednisolone – what it is, how to use it safely and possible side effects. Methylprednisolone is commonly called Medrol, Solu-Medrol, or Depo-Medrol.

Type of medicine Also called
  • Belongs to a group of medicines known as corticosteroids
  • Medrol®
  • Solu-Medrol®
  • Depo-Medrol

What is methylprednisolone?

Methylprednisolone is a medicine used to treat many illnesses associated with inflammation, such as inflammatory bowel diseases (eg, Crohn's disease, ulcerative colitis), autoimmune diseases (eg, systemic lupus erythematosus, multiple sclerosis) or joint and muscle diseases (eg, rheumatoid arthritis). It is also used to treat severe allergic reactions or acute transplant rejection.

Methylprednisolone works by calming or suppressing your body's immune system and is especially effective for treating flare-ups of these conditions. Methylprednisolone helps to reduce the symptoms associated with these conditions – it does not cure them.

Methylprednisolone is in a class of medicines known as corticosteroids, which is similar to the steroid hormones your body naturally makes. It is available as tablets or as an injection that can be given into your vein or muscle. 


  • The dose of methylprednisolone is different for different people.
  • Most people may need a short course of methylprednisolone (such as 3–5 days), but some may need to take it for longer (weeks to months).
  • Always take your methylprednisolone exactly as your doctor has told you.
  • The pharmacy label on your medicine will tell you how much methylprednisolone to take, how often to take it and any special instructions.

How to take methylprednisolone

  • Timing: Take your methylprednisolone tablets with food. Methylprednisolone is best taken in the morning, with breakfast. Swallow your tablets with a glass of water.
  • Missed dose: If you forget to take your dose, take it as soon as you remember. But if it is nearly time for your next dose, just take the next dose at the right time. Do not take double the dose.
  • Stopping methylprednisolone: If you have been taking methylprednisolone regularly for longer than 2 weeks, do not stop it suddenly. Stopping suddenly can cause withdrawal symptoms, which can be serious, or even life threatening. Instead, you will be given a tapering dose. This means your dose of methylprednisolone will be gradually reduced over a few days or weeks.

Precautions when taking methylprednisolone

Before starting methylprednisolone

  • Do you have problems with your heart or blood pressure?
  • Do you have diabetes, epilepsy or osteoporosis?
  • Do you have problems with your liver or kidneys?
  • Do you have problems with your stomach or stomach ulcers?
  • Do you have glaucoma?
  • Are you pregnant or breastfeeding?
  • Have you experienced psychosis or a psychiatric reaction to steroids before?
  • Do you play competitive sport?
  • Are you taking or using any other medicines? This includes any medicines available to buy without a prescription, as well as herbal and complementary medicines.

If so, it’s important that you tell your doctor or pharmacist before you start methylprednisolone. Sometimes a medicine isn’t suitable for a person with certain conditions, or it can only be used with extra care.

While taking methylprednisolone

  • Tell any healthcare provider: It's important to tell any healthcare provider taking care of you that you are taking methylprednisolone.
  • Increased risk of infections: Taking methylprednisolone for a long time can increase your risk of all types of infections. Tell your doctor if you come into contact with someone who has a contagious illness, such as chickenpox, shingles or measles, or if you feel unwell.
  • Vaccines: It is safe to have most vaccines, including the flu vaccine, while you are taking methylprednisolone. Protecting yourself against infection is important because methylprednisolone suppresses your immune system. However, vaccination with 'live vaccines' should be postponed. Ask your doctor for advice before you have any vaccinations while you are taking methylprednisolone.

Side effects

Like all medicines, methylprednisolone can cause side effects, although not everyone gets them. Most side effects are related to the dose you are taking and how long you are taking methylprednisolone for. Read more about taking steroids long term.

Side effects What should I do?
  • Difficulty sleeping
  • Take methylprednisolone in the morning or at least 3 hours before bedtime.
  • Headache
  • Muscle weakness
  • Feeling tired
  • These are quite common when you first start taking methylprednisolone and usually go away with time.
  • Tell your doctor if troublesome.
  • Increased appetite (wanting to eat more)
  • Methylprednisolone increases your appetite.
  • Follow a healthy, balanced diet to maintain your weight.
  • Fluid retention causing swollen ankles and feet
  • Whenever possible, sit with your feet raised.
  • Avoid foods with high salt content.
  • Tell your doctor if this happens.
  • Raised blood glucose
  • Methylprednisolone can cause an increase in blood glucose.
  • If you have diabetes, you may need to increase the dose of your diabetic medicine to control your blood glucose. Talk to your doctor about this.
  • Methylprednisolone can also cause the onset of diabetes in people who are at risk of diabetes.
  • Your doctor will monitor your blood glucose levels regularly.  
  • Changes in mood or behaviour
  • Mood swings, irritability, anxiety, bad dreams
  • Tell your doctor immediately or phone Healthline 0800 611 116.
  • Eye pain and changes to your vision
  • Tell your doctor immediately or phone Healthline 0800 611 116.
  • Problems with your stomach such as stomach pain, blood in your stool (poos) or dark-coloured stool (poos)
  • Tell your doctor immediately or phone Healthline 0800 611 116.


Methylprednisolone interacts with a number of medicines and herbal supplements, so check with your doctor or pharmacist before starting methylprednisolone and before starting any new medicines.

Learn more

The following links provide further information on methylprednisolone. Be aware that websites from other countries may contain information that differs from New Zealand recommendations.

Methylprednisolone tablets Patient Info, UK 

Credits: Sandra Ponen, Pharmacist. Reviewed By: Angela Lambie, Pharmacist, Auckland Last reviewed: 22 Dec 2020