Febuxostat

Sounds like 'feb-ux-oh-stat'

Easy-to-read medicine information about febuxostat – what it is, how to take febuxostat safely and possible side effects.

Type of medicineAlso called
  • Anti-gout medication
  • Belongs to a group of medicines known as xanthine oxidase inhibitors
  • Adenuric®

What is febuxostat?

  • Febuxostat is used to prevent gout attacks and gouty arthritis.
  • It works on the kidneys to help the body remove excess uric acid.
  • It is used when other medications such as allopurinol cannot be taken or have not lowered uric acid levels adequately.
  • Read more about gout.

Dose

  • The dose of febuxostat is 80 mg once daily.
  • Depending on your response, your doctor may increase your dose after 2 to 4 weeks, to 120 mg once daily.
  • Always take your febuxostat exactly as your doctor has told you. The pharmacy label on your medicine will tell you how much febuxostat to take, how often to take it, and any special instructions.

How to take febuxostat

  • Take febuxostat at the same time each day. It is best taken in the morning.
  • You can take febuxostat with or without food.
  • Keep taking febuxostat every day, to prevent gout attacks. It may take a few weeks before you experience the full benefits of febuxostat.
  • Limit or avoid alcohol while you are taking febuxostat.
  • If you forget to take your tablet, take it as soon as you remember that day.
  • But, if it is nearly time for your next tablet, just take the next tablet at the right time. Do not take double the amount of tablets.
  • Do not stop taking febuxostat suddenly; speak to your doctor or nurse before stopping.

Special instructions

  • When you first start taking febuxostat, you can still have gout attacks. Keep taking febuxostat, since it takes a while to fully work. Your doctor will prescribe additional medication such as a non-steroidal anti-inflammatory (NSAID) or colchicine to settle the attack.    
  • When taking febuxostat you will need to have blood tests to monitor your liver function and uric acid levels.

Possible side effects

Like all medicines, febuxostat can cause unwanted side effects, although not everyone gets them. Often unwanted side effects improve as your body gets used to the new medicine.

Side effectsWhat should I do?
  • Headache
  • Feeling sick or vomiting
  • Diarrhoea
  • These are quite common when you first start taking febuxostat, and usually go away with time.
  • Tell your doctor if troublesome.
  • Dizziness
  • Sleepiness
  • Blurred vision
  • Be careful when driving or using tools until you know how this medicine affects you.
  • Signs of an allergic reaction such as sudden redness of the skin, skin rashes, itching, swelling of the face, lips, or mouth, and problems breathing, such as short of breath or wheezing
  • Stop taking febuxostat
  • Tell your doctor immediately or ring HealthLine on 0800 611 116


  • Signs of problems with your liver such as yellowing of the skin or eyes, dark urine, pain in the abdomen.
  • Tell your doctor immediately or ring HealthLine on 0800 611 116

Interactions

  • Febuxostat may interact with a number of important medications and herbal supplements so check with your doctor or pharmacist.

Learn more

Medsafe Consumer Information Sheet Adenuric

Credits: Sandra Ponen, Pharmacist. Reviewed By: Dr J Bycroft. Health Navigator NZ