Clexane

Also called enoxaparin

Clexane is an anticoagulant. It is used to treat and prevent blood clots, which can block your blood vessels. Find out how to use it safely and possible side effects. Clexane is also called enoxaparin.

What is Clexane?

Clexane is an anticoagulant. Anticoagulants are often referred to as ‘blood thinners’ but they actually work by interrupting the clot-forming process and increasing the time it takes for blood clots to form. This helps prevent blood clots from forming and stops existing clots from growing bigger.

Clexane is often prescribed after operations (surgeries) such as hip or knee surgery, or abdominal surgery, when your risk of getting blood clots is increased. Clexane is also used if a blood clot has already formed in your heart (heart attack), leg (deep vein thrombosis) or lungs (pulmonary embolism).

Clexane is given as an injection under your skin. It comes as a pre-filled syringe, which means the syringe comes already with the medicine in it. It is ready for use.

How to use Clexane

The dose of Clexane is different for different people, depending on its use, your body weight and how well your kidneys are working. Your doctor will work out the best dose for you. The dose is usually given once or twice daily.

Clexane is given as an injection just under your skin (called subcutaneous injection).

Note: There are 2 Clexane injection devices. In July 2020 a new Clexane device with safety lock injection replaced the old Clexane device without safety lock injection.  

If you are unsure about how to inject Clexane, ask your doctor, nurse or pharmacist to show you.

Video on how to inject Clexane®

If you click on the arrow below, you can watch 2 videos, one for the Clexane device with safety lock and one for the old Clexane device without a safety lock.

If you can't inject Clexane yourself, ask a family/whānau member or somebody you live with to learn how to give you the injection. If this is not possible, your GP may be able to arrange for a nurse to give you the injections in your home, or for you to go to a clinic. 

Handy tips when using Clexane

  • Dose: Your healthcare provider will teach you how to measure your dose. You may need to use all of the syringe or you may need to discard some first. You may notice an air bubble in the syringe. This is supposed to be there. Do not try to remove it. Inject your Clexane dose at the same time each day.   
  • Injection site: Change injection sites each time to stop your skin from hardening.
  • Missed dose: If it is nearly time for your next dose, skip the missed dose and inject your next dose at the usual time. Otherwise, inject the missed dose as soon as possible. Do not inject 2 doses at the same time. Contact your doctor if you miss 2 or more doses in a row.
  • Tell your healthcare providers: It is important to let your health professionals know that you are taking Clexane, such as your dentist, pharmacist, podiatrist or nurse.
  • Storage: Keep your Clexane syringes at room temperature. Do not put them in the fridge or freezer.
  • Used syringes: Keep used syringes in a hard plastic container (such as an empty detergent bottle) with a lid. You can take the container to your local pharmacy to be disposed of safely. Do not reuse syringes.

Image: VTE Matters, NZ 

What are the side effects of enoxaparin?

Like all medicines, Clexane can cause side effects, although not everyone gets them. Common side effects include pain, itch, swelling or rash at the injection site. These may go away with time. Tell your doctor if any side effects continue to bother you.

Increased risk of bleeding

Taking Clexane means that your blood takes longer to form clots. This can increase your risk of bleeding. The benefits of using anticoagulants usually outweigh the risks of bleeding and your doctor will consider this before starting treatment.

You might bleed or bruise more easily while you are taking Clexane.

  • Be careful when shaving, clipping your fingernails, brushing and flossing your teeth, or playing sports. 
  • Don't get any new tattoos or piercings or have any deep-tissue massage while you are taking Clexane, as these things may cause bruising and bleeding.
  • Minor bleeding should usually stop on its own. If you have a fall or hurt your head or body, get medical attention immediately, even if you feel okay.

Did you know that you can report a side effect to a medicine to CARM (Centre for Adverse Reactions Monitoring)? Report a side effect to a product


Signs of severe bleeding

Contact your doctor immediately or phone Healthline on 0800 611 116 for free 24-hour advice if you have any of the following signs of bleeding:

  • becoming pale, very weak and tired, or short of breath
  • any bleeding from your gums
  • cuts or nosebleeds that won’t stop (longer than 10 minutes)
  • blood in your stools (poo) – black, tarry stools
  • blood in your urine (pee) – pink, red or brown-coloured urine
  • heavy periods (menstrual bleeding)
  • coughing up blood
  • vomiting up something that looks like coffee grounds.

Interactions with other medicines

Clexane should not be taken with some other medicines and herbal supplements. Tell your doctor or pharmacist about all medicines you are taking (including over-the-counter medicines), herbal and complementary medicines, or recreational drugs. Your doctor or pharmacist will check for any interactions. 

The following may increase your risk of bleeding and should be avoided:

  • over-the-counter anti-inflammatories such as diclofenac (eg, Voltaren Rapid), ibuprofen (eg, Nurofen) or naproxen (eg, Naprogesic)
  • herbal extracts such as garlic, ginkgo or ginseng. 

Learn more

Clexane Medsafe, NZ
Enoxaparin NZ Formulary 

References

  1. Low molecular weight heparin use in primary care BPAC, NZ, 2009
  2. Enoxaparin Institute of Safe Medication Practice (ISMP), US

Additional resources for healthcare professionals

Anticoagulants and reversal agents NZ Formulary

Credits: Sandra Ponen, Pharmacist. Reviewed By: Maya Patel, MPharm PGDipClinPharm, Auckland Last reviewed: 20 Oct 2021