Ocrelizumab

Ocrelizumab is given in hospital by slow injection into a vein in your arm (called intravenous infusion). The infusion usually takes 2 to 3.5 hours. You’ll be monitored for side effects for an hour after the infusion.

• You get the first dose as 2 separate infusions, 2 weeks apart.
• After that you have an infusion once every 5 to 6 months.

During the infusion

Ocrelizumab can cause a reaction while it's being given so you’ll be carefully monitored during the infusion and for at least 1 hour afterwards. You will be monitored to see if you have trouble breathing, or experience fever, chills, flushing, skin rash, itching, dizziness or headache. Tell the nurse immediately if any of these symptoms occur. These are usually more common on your first infusion. Your doctor or nurse may slow down the infusion or stop it until these symptoms go away. You will also be given medicines (eg, paracetamol and an antihistamine) shortly before the infusion to help control this reaction. 

Here are some things to know when you're taking ocrelizumab. Other things may be important as well, so ask your healthcare provider what you should know about.

• Reaction during the infusion: Ocrelizumab may cause an infusion-related reaction for up to 24 hours after you've received a dose. It’s important that you tell your doctor or go to the Accident and Emergency at your nearest hospital if you notice any unusual symptoms. See side effects below.
• Increased risk of infections: Ocrelizumab weakens your body’s defence (immune) system, so you're more likely to pick up infections. It's important to avoid anyone who has chickenpox or shingles.
• Pregnancy: You should avoid becoming pregnant while you are having ocrelizumab and for at least 6 months after your last dose. Talk to your healthcare provider about which types of contraception are suitable for you and your partner. Tell your healthcare provider if you become pregnant while using ocrelizumab.
• Vaccines: Some vaccines shouldn't be taken if you are on ocrelizumab. Always check with your doctor or pharmacist first. It's safe for you to have the annual flu vaccine.
• Other medicines: Ocrelizumab may interact with a few medicines and herbal supplements, so check with your doctor or pharmacist before starting ocrelizumab or before starting any new medicines, including those you may buy over-the-counter.

Like all medicines, ocrelizumab can cause side effects, although not everyone gets them. Often side effects improve as your body adjusts to the new medicine.