Examples of TNF inhibitors
- adalimumab (Humira®)
- etanercept (Enbrel®)
- infliximab (Remicade®)
- ustekinumab (Stelara®)
What are TNF inhibitors
- TNF inhibitors are used to treat certain types of autoimmune conditions (diseases in which the body's defense system or immune system attacks healthy tissues) such as:
- TNF inhibitors work by blocking natural substances in the body called tumor necrosis factor alpha. This helps to decrease swelling (inflammation) and weaken your immune system, thereby slowing or stopping the damage from the disease.
TNF inhibitors are expensive medications with a potential for serious side effects. They are used in selected patients when standard treatments have been unsuccessful. In New Zealand TNF inhibitors are funded subject to restrictions (Pharmac subsidy restrictions). To qualify for subsidy the initial application for treatment must come from an appropriate named specialist, e.g. a rheumatologist, gastroenterologist or dermatologist.
How are TNF inhibitors given
TNF inhibitors are given by injection.
- adalimumab, etanercept and ustekinumab are given by subcutaneous injection (into the skin), usually in the thigh or abdomen (tummy area).
- Change the site for each injection.
- Do not inject in an area that is bruised, red, hard, or tender.
- infliximab is given by intravenous infusion (as a drip) into the vein.
Monitoring and investigations
TNF inhibitors have the potential for serious side effects, including the increased risk of infection.
- Before prescribing a TNF inhibitor, your doctor will test for a range of infections such as tuberculosis (TB), hepatitis, chicken pox.
- To monitor the safety of TNF inhibitors and to observe how well they are working, your doctor will order a variety of laboratory tests before you start treatment and every few weeks, while you are on it. Common tests are full blood count, liver function test, C-reactive protein test.
Before starting on a TNF inhibitor, your doctor will review your immunisation record to ensure you have received all vaccinations recommended on the New Zealand immunisation schedule. Sometimes it may be necessary to plan an immunisation catch-up.
- Live vaccinations, such as varicella vaccine, tuberculosis (BCG) and measles, mumps rubella (MMR), must be avoided if you are receiving treatment with a TNF inhibitor and should be completed before starting treatment.
- The following vaccines are safe to take while receiving treatment with a TNF inhibitor:
- Hepatitis A and B vaccine
- Influenza vaccine
- Vaccine against pneumococcal infection
Possible side effects
|Side effects||What should I do?|
Medsafe Consumer Information Sheet