Sounds like 'pram-ih-PEX-ole'

Pramipexole is used to treat the symptoms of Parkinson's disease. Find out how to take it safely and possible side effects. Pramipexole is commonly called Ramipex.

Type of medicine Also called
  • Dopaminergic medicine
  • Belongs to a group of medicines to treat Parkinson's disease
  • Also used to treat restless legs syndrome
  • Ramipex®

What is pramipexole?

  • Pramipexole is used to treat the symptoms of Parkinson's disease, or Parkinson-like symptoms such as tremor, shakiness, stiffness, and difficulty moving.
  • It works by helping to restore the balance of dopamine in your brain. Dopamine is a chemical in the brain that helps to control movement.  
  • Pramipexole is also used to treat restless legs syndrome. It helps to reduce the urge to move your legs and the feelings you get with restless legs syndrome.
  • Pramipexole is available as tablets.


  • The dose of pramipexole is different for different people.
  • You will be started on a low dose at first, and your doctor will increase your dose slowly, to control your symptoms. This reduces your chances of side effects and helps your body to get used to the medicine.
  • Always take your pramipexole exactly as your doctor has told you. The pharmacy label on your medicine will tell you how much pramipexole to take, how often to take it, and any special instructions.

How to take pramipexole

  • You can take pramipexole with or without food. Try taking pramipexole with food if it causes nausea (feeling sick).
  • Try to take your pramipexole at the same times of day each day.
  • For Parkinson's disease, pramipexole is usually taken 3 times a day, and for restless legs syndrome, pramipexole is taken once a day, about 2 to 3 hours before bed.
  • If you do miss a dose then take your next dose when it is due. Do not take double the dose.  
  • Keep taking pramipexole regularly. Stopping treatment suddenly can cause serious problems.

Possible side effects

Like all medicines, pramipexole can cause side effects, although not everyone gets them. Often side effects improve as your body gets used to the new medicine.

Side effects What should I do?
  • Feeling or being sick (nausea)
  • This is common when you first start taking pramipexole
  • Take your doses after food
  • Falling asleep suddenly during daily activities (such as talking on the phone, or driving)
  • This sleep effect can occur without any feelings of drowsiness beforehand, and can happen anytime during treatment with this medication
  • Tell your doctor
  • Do not drive or use tools until you know how this medicine affects you and until these have stopped happening
  • Avoid drinking alcohol
  • Feeling dizzy or faint when you stand up (due to a sudden drop in blood pressure)
  • Be careful when getting up from either lying down or sitting, to avoid falls
  • Tell your doctor
  • Impulsive types of behaviour or intense urges that are difficult to control such as binge eating, gambling and increased sexual urges
  • Tell your doctor immediately or ring HealthLine 0800 611 116
  • Uncontrollable jerky movements, where you switch suddenly from being able to move to being immobile
  • Tell your doctor immediately or ring HealthLine 0800 611 116


Pramipexole interacts with a number of important medications and herbal supplements, so check with your doctor or pharmacist.

Learn more

The following links provide further information on pramipexole. Be aware that websites from other countries may contain information that differs from New Zealand recommendations.

Pramipexole tablets Patient Info, UK.

Credits: Sandra Ponen, Pharmacist. Reviewed By: Angela Lambie, Pharmacist, Auckland Last reviewed: 08 Dec 2016