Sounds like 'per-in-doe-pril'

Easy-to-read medicine information about perindopril – what it is, how to take it safely and possible side effects. Perindopril is also called Coversyl.

Type of medicine Also called
  • Belongs to a group of medicines called ACE inhibitors
  • Coversyl

What is perindopril?

Perindopril has many different effects on your body so it is used to treat a range of conditions. It belongs to a group of medicines called ACE inhibitors.

Perindopril may be used for the following conditions:

  • High blood pressure – by relaxing and widening your blood vessels it lowers your blood pressure.
  • Heart failure – to help your heart pump blood more easily. This can help to relieve symptoms such as shortness of breath and swelling in your feet, legs and abdomen (tummy).
  • Diabetic kidney disease (diabetic nephropathy) – to protect your kidneys and help them to function.

Perindopril can work quickly for hypertension (high blood pressure). If you have heart failure it may be a few weeks before you notice an improvement in your symptoms. Once you have started perindopril you usually keep taking it for life, unless you have a serious side effect. In New Zealand perindopril is available as tablets.


Perindopril tablets are available in different strengths: 2 mg and 4 mg. 

  • Your doctor will tell you the dose that is right for you.
  • Your dose of perindopril will depend on what it is being used for.
  • Your doctor will usually start you on a low dose and increase the dose depending on how you respond. This allows your body to get used to the medicine and reduces side effects.
  • Perindopril is usually taken once a day.
  • Always take your perindopril exactly as your doctor has told you. The pharmacy label on your medicine will tell you how much to take, how often to take it and any special instructions.
  • Check with your pharmacist if your tablets are different to what you expect.

My dose

Date Dose

How to take perindopril

  • Timing: Perindopril is usually taken once a day. Take your perindopril dose at the same time each day. It is best taken in the morning. Take each dose on an empty stomach, 1 hour before OR 2 hours after food.
  • Limit or avoid alcohol while you are taking perindopril. Alcohol can increase your chance of side effects such as dizziness and light-headedness.
  • Missed dose: If you forget to take your dose, take it as soon as you remember. But if it is nearly time for your next dose, just take the next dose at the right time. Do not take double the dose.

Cautions while you are taking perindopril

Have a sick day plan

If you have diarrhoea (runny poo) or are vomiting (being sick) from a stomach bug, or have dehydration from other causes, it’s important to let your GP know, as they may advise you to stop taking your perindopril for a few days and start again when you feel better. 

Be careful when taking some pain relief medicines

ACE inhibitors can be used to protect your kidneys from damage if you have diabetes. However, if you are taking perindopril and diuretics (water pills), the combination of these with NSAIDs (anti-inflammatory pain relief medicine) can be very harmful to your kidneys. It can cause acute kidney injury. This combination is called the ‘dangerous trio’ or ‘triple whammy’. You have a higher risk of harm to your kidneys if you are also an older adult (over 65 years) or are dehydrated. 

If you are taking an ACE inhibitor with a diuretic, do not use NSAIDs for pain relief. Ask your doctor or pharmacist for a safer option. Read more about NSAIDs and protecting your kidneys.

Examples of diuretics Examples of NSAIDs
  • Bendroflumetazide (Arrow-Bendrofluazide)
  • Chlortalidone (Hygroton)
  • Indapamide (Dapa-Tabs)
  • Metolazone (Zaroxolyn)
  • Furosemide (Lasix)
  • Bumetanide (Burinex)
  • Spironolactone (Spiractin)
  • Ibuprofen (Ibugesic, I-Profen, Nurofen)
  • Diclofenac (Voltaren)
  • Naproxen (Noflam, Naprosyn)
  • Mefenamic acid (Ponstan)
  • Celecoxib (Celebrex)
  • Tenoxicam (Tilcotil)

Are you pregnant or planning a pregnancy?

Tell your doctor if you become pregnant or are planning a pregnancy while you are taking perindopril.

What are the side effects of perindopril?

Like all medicines perindopril can cause side effects, although not everyone gets them. Often side effects improve as your body gets used to the new medicine.

Side effects What should I do?
  • Dizziness
  • Feeling light-headed
  • Feeling faint when you stand up
  • This is quite common when you first start taking perindopril and usually goes way with time.
  • These effects put you at risk of falls and injuries, especially if you are an older adult. Be careful when getting up from either lying down or sitting. 
  • Stand up slowly. If you do feel dizzy, sit or lie down for a few moments.
  • Tell your doctor if this continues.
  • Tickle in your throat
  • Dry, irritating cough

  • This is quite common when you first start taking perindopril and usually goes away with time.
  • Tell your doctor if the cough is troublesome and persistent.
  • Allergic reaction such as skin rash, itching, swelling of your lips, face and mouth, or difficulty breathing, such as chest tightness or wheezing
  • Tell your doctor immediately or phone Healthline 0800 611 116.
  • Signs of problems with your liver, such as yellowing of your skin or eyes, dark pee or pain in your abdomen (tummy)
  • Tell your doctor immediately or phone Healthline 0800 611 116.
Did you know that you can report a side effect to a medicine to CARM (Centre for Adverse Reactions Monitoring)? Report a side effect to a product


  • Perindopril interacts with a few medicines and herbal supplements, so check with your doctor or pharmacist before starting perindopril and before starting any new medicines.
  • Also, check with your pharmacist before taking over-the-counter medicines, including:
    • anti-inflammatories such as diclofenac (eg, Voltaren Rapid)
    • ibuprofen (eg, Nurofen)
    • naproxen (eg, Naprogesic).

Learn more

The following links provide more information on perindopril.

Perindopril NZ Formulary Patient Information


  1. Perindopril NZ Formulary
Credits: Sandra Ponen, Pharmacist. Reviewed By: Maya Patel, MPharm PGDipClinPharm, Auckland Last reviewed: 22 Apr 2021