Sounds like 'pan-TO-pra-zol'

Pantoprazole is used to treat problems affecting the stomach and gut, such as indigestion, reflux and ulcers. Find out how to take it safely and possible side effects. Pantoprazole is also called Panzop Relief.

Type of medicine Also called
  • Medicine to reduce stomach acid
  • Belongs to a group of medicines known as proton pump inhibitors
  • Panzop Relief®
  • Pantoprazole (Dr Reddy's)®
  • Pantoprazole (Actavis)®
  • Pantoprazole (Sandoz)®

What is pantoprazole?

Pantoprazole reduces the amount of acid produced in your stomach. It belongs to a group of medicines known as proton pump inhibitors (PPIs). They are used to treat a number of conditions associated with high stomach acid affecting your stomach and gut, such as indigestion, reflux and ulcersPantoprazole can prevent ulcers from forming, or help the healing process where damage has already occurred.

Pantoprazole can be given together with antibiotics to get rid of Helicobacter pylori, a bacteria found in the stomach that can cause ulcers.

Pantoprazole can be used to prevent ulcers caused by medicines such as non-steroidal anti-inflammatory drugs (NSAIDs). Examples of NSAIDs are diclofenac, ibuprofen and naproxen.

In New Zealand pantoprazole is available as tablets.


  • The usual dose of pantoprazole is 20 to 40 mg once a day.
  • Your doctor will advise you how long to take pantoprazole for (usually for 2 to 4 weeks). Some people may need to take it for longer.
  • It is best to take the lowest effective dose, for the shortest possible time.
  • The pharmacy label on your medicine will tell you how much pantoprazole to take, how often to take it and any special instructions.

How to take pantoprazole

  • Timing: Take pantoprazole at the same time each day, usually in the morning. Pantoprazole can be taken before or after food, although taking it before food is best.
  • Swallow your tablet whole with a glass of water. Do not crush or chew – the medicine doesn't work properly if the tablet is crushed or chewed.
  • Missed dose: If you forget to take your dose, take it as soon as you remember. But, if it is nearly time for your next dose, just take the next dose at the right time. Do not take double the dose.

Avoid long-term use – choose wisely

If you don’t need them, PPIs like pantoprazole should not be taken long term, because of the possible side effects. There may be a small increased risk of bone fractures, chest infections, kidney problems and nutrient deficiencies such as low magnesium and low vitamin B12. If you’ve been taking a PPI for reflux for longer than 4 to 8 weeks, and your symptoms seem to be well managed, it’s a good idea to talk to your healthcare provider about reviewing your medicine. They may recommend stepping down your treatment. This could include:

  • reducing your daily dose of pantoprazole
  • taking pantoprazole only when you experience the symptoms of heartburn and reflux (also known as on-demand therapy)
  • stopping treatment completely, as your symptoms may not return. It may be best to reduce the dose over a few weeks before stopping.

Read more about PPIs for heartburn and reflux Choosing Wisely, NZ 

Precaution before starting pantoprazole

  • Are you pregnant, planning a pregnancy or breastfeeding?
  • Do you have problems with your kidneys or liver?
  • Are taking any other medicines? This includes any medicines you are taking which you can buy without a prescription, as well as herbal and complementary medicines.

If so, it’s important that you tell your doctor or pharmacist before you start pantoprazole. Sometimes a medicine isn’t suitable for a person with certain conditions, or it can only be used with extra care.

What are the side effects of pantoprazole?

Like all medicines, pantoprazole can cause side effects, although not everyone gets them. Often side effects improve as your body adjusts to the new medicine.

Rebound acid secretion

When pantoprazole is stopped, a common side effect is rebound acid secretion, where the acid secretion in your stomach increases significantly. This should return to normal within 2 weeks. Because the symptoms of rebound acid secretion are the same as for reflux (such as indigestion, discomfort and pain in your upper stomach and chest, feeling sick and an acid taste in your mouth), it can form an ongoing loop where stopping pantoprazole treatment creates the need to start it again.

Rather than restart pantoprazole, your doctor may advise you to use medicines that contain both an antacid and an anti-foaming agent, such as Acidex oral liquid or Gaviscon Double Strength tablets. Alternatively, ranitidine tablets could be used. These can be effective for treating rebound acid secretion. You can use these medicines to relieve the symptoms when they occur.

Talk to your doctor or pharmacist about how to manage rebound acid secretion.

Other side effects

Side effects What should I do?
  • Stomach upset, feeling sick
  • Feeling bloated, gas in your abdomen (tummy)
  • Diarrhoea
  • Constipation
  • These are quite common when you first start taking pantoprazole.
  • Tell your doctor if troublesome.
  • Signs of low magnesium, such as muscle cramps, weakness, tiredness, feeling irritable and changes in heartbeat
  • Increase your intake of magnesium-rich foods such as wholegrain cereals, green leafy vegetables (spinach, parsley, cabbage), peas, lean meats, nuts, seeds and bananas
  • Tell your doctor if troublesome – you may need a magnesium supplement.
  • Severe diarrhoea (loose, watery, frequent stools)  
  • Pantoprazole can increase the chance of getting severe diarrhoea (which may be caused by a bacteria called clostridium difficle).
  • Stop pantoprazole and tell your doctor immediately.
  • Signs of an allergic reaction, such as rash, fever, painful joints
  • Tell your doctor immediately or ring HealthLine 0800 611 116.
  • Worsening stomach problems, such as really bad stomach pain, blood in your stools or black stools, vomiting blood or dark-coloured vomit
  • Tell your doctor immediately or ring HealthLine 0800 611 116.
Did you know that you can report a side effect to a medicine to CARM (Centre for Adverse Reactions Monitoring)? Report a side effect to a product


Pantoprazole may interact with a few medications and herbal supplements, so check with your doctor or pharmacist before starting pantproazole or before starting any new medicines.

Learn more

New Zealand Formulary Patient Information: Pantoprazole


  1. Stopping proton pump inhibitors in older people BPAC, NZ 2019
  2. Proton pump inhibitors – when is enough, enough? BPAC, NZ, 2014
  3. Proton pump inhibitors and the risk of acute kidney injury BPAC, NZ, 2016
  4. Pantoprazole New Zealand Formulary

Additional resources for healthcare professionals

Interaction – methotrexate and proton pump inhibitors Medsafe, NZ, 2013
Hypomagnesaemia – a risk associated with all proton pump inhibitors Medsafe, NZ, 2012
Proton pump inhibitors and interstitial nephritis Medsafe, NZ, 2011
Hypomagnesaemia with proton pump inhibitors BPAC, NZ, 2013
Managing dyspepsia and heartburn in general practice – an update BPAC, NZ, 2011
Audits – identifying patients who may benefit from “stepping down” omeprazole treatment BPAC, NZ, 2016
Clostridium difficile-associated diarrhea can be associated with stomach acid drugs known as proton pump inhibitors (PPIs) FDA Drug Safety Communication, US, 2017
Low magnesium levels can be associated with long-term use of proton pump inhibitor drugs (PPIs) FDA Drug Safety Communication, US, 2017
Possible increased risk of fractures of the hip, wrist, and spine with the use of proton pump inhibitors FDA Drug Safety Communication, US, 2017

Credits: Sandra Ponen, Pharmacist. Reviewed By: Angela Lambie, Pharmacist, Auckland Last reviewed: 19 Feb 2019