Medicines and bladder control problems

Medicines can be helpful for treating bladder control problems. However, for some people medicines can affect bladder control which can make it difficult to get to the toilet on time.

On this page, you can find the following information:

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How can medicines cause bladder control problems?

Some medicines can affect your bladder and can cause or make bladder control worse. These include some herbal products and medicines bought over the counter at the pharmacy.  

Different medicines may do this in different ways and sometimes it's a combination of medicines that can make the problem worse. This is more likely for older people or those who are taking a lot of medicines. 

For example, medicines may:

  • Increase urine production (eg, diuretics – also called water pills).
  • Relax the the bladder which leads to urinary retention, or difficulty in starting to pee or straining while peeing.
  • Relax the muscle at the outlet of the bladder which may cause leaking when coughing, sneezing or laughing.
  • Relax the urethra leading to frequent peeing.
  • Cause coughing which can cause stress incontinence.

Weak pelvic floor muscles, or an enlarged prostate can also contribute to bladder symptoms. Read more about bladder control problems and pelvic floor exercises for women and men.

Is my medicine causing my bladder problem?

Not all bladder problems are caused by medicines, so working out if your symptoms are caused by your medicine is not always easy. If you have noticed a change in bladder control when you started a new medicine or when you increased the dose of a medicine you were already taking, it could be because of your medicine. 

If you are taking a medicine and are worried about your bladder problem don't stop taking your medicine suddenly. Instead discuss this with your doctor or pharmacist.

Sometimes there might be a different medicine you can take that has less effect on your bladder. Also, the risks of stopping or changing medicines should be balanced against the risks of bladder problems and other health effects.

Examples of medicines that can cause bladder control problems

  • Diuretics such as furosemide, bumetanide, bendrofluazide.
  • Antipsychotics such as risperidone, clozapine, olanzapine, quetiapine.
  • Antidepressants such as amitriptyline, nortriptyline, doxepin, imipramine.
  • Calcium channel blockers such as nifedipine, felodipine, amlodipine, diltiazem, verapamil.
  • Antihistamines such as chlorphenamine (Histafen®), dexchlorpheniramine (Polaramine®), promethazine (Phenergan®, Allersoothe®), cetirizine, desloratadine, fexofenadine, levocetirizine, loratadine.

Note: This is not a complete list. If you are unsure if the medicine you are taking can cause bladder control problems, ask your doctor or pharmacist.


  1. Drug-induced urinary incontinence US Pharmacist, 2014
Credits: Sandra Ponen, pharmacist. Reviewed By: Angela Lambie, Pharmacist, Auckland Last reviewed: 16 Aug 2022