Glecaprevir and pibrentasvir

Also called Maviret

Easy-to-read medicine information about glecaprevir and pibrentasvir, commonly known as Maviret®; what it is, how to take Maviret safely and possible side effects.

Type of medicine Also called
  • Antiviral medicine
  • Medicine to treat chronic hepatitis C  
  • Maviret®

What is Maviret?

Maviret is a combination of two medicines, glecaprevir and pibrentasvir. It is used to treat chronic hepatitis C (hep C), a viral infection of the liver. It works against all genotypes of hepatitis C virus. 

Maviret is made up of 2 medicines (glecaprevir and pibrentasvir) in a single tablet that work together to stop the hep C virus from multiplying. When taken as directed by new patients, Maviret cures hepatitis C in 98% of cases. 

Maviret will not prevent you from getting hep C in the future. You should take precautions to avoid re-infection.

Getting your supply of Maviret

Maviret is only available from some pharmacies. Find your nearest pharmacy. After your doctor has written your prescription, take it to one of these pharmacies. The pharmacist will order your Maviret and contact you when it’s ready to pick up (this may take a few days). You will usually get a 1-month supply of Maviret each time you visit until you finish your treatment. You will not have to pay pharmacy fees when you collect your Maviret each month. If you are unable to get to one of the pharmacies on the list, talk to your doctor or nurse about other options.

Dose

  • The dose of Maviret is 3 tablets once daily. 
  • Your doctor will advise you how long to take Maviret for (usually 8 weeks).
  • Always take your Maviret exactly as your doctor has told you. The pharmacy label on your medicine will tell you how much Maviret to take, how often to take it, and any special instructions.

How to take Maviret

  • Swallow your Maviret tablets whole with a glass of water.
  • Do not crush, chew or break the tablets.
  • Take your Maviret tablets with food – either a snack like a banana, or yoghurt or have a
    full meal. 
  • Maviret tablets are best taken about the same time each day.
  • If you miss a dose:
    • Within 18 hours of your usual dose time: take your missed dose and then continue your regular dosing.
    • More than 18 hours from your usual dose time: skip the dose and take the next dose at the usual time.
  • Keep taking your Maviret tablets for the full time it has been prescribed, even if you feel well. 

Precautions – before starting Maviret

  • Are you pregnant, planning a pregnancy or breastfeeding?
  • Have you had or do you have hepatitis B infection?
  • Have you had a liver transplant?
  • Do you have HIV infection?
  • Are you taking any other medicines? This includes any medicines you buy without a prescription, such as herbal and complementary medicines?

If so, it’s important that you tell your doctor or pharmacist before you start Maviret. Sometimes a medicine isn’t suitable for a person with certain conditions, or it can only be used with extra care.

Possible side effects

Like all medicines, Maviret can cause side effects, although not everyone gets them. Often side effects improve as your body gets used to the new medicine.

Hepatitis B virus reactivation

Before starting treatment with Maviret, your doctor will do blood tests to check for hepatitis B virus infection. If you have ever had hepatitis B virus infection, the hepatitis B virus could become active again during or after treatment with Maviret. Your doctor will monitor you if you are at risk for hepatitis B virus reactivation during treatment and after you stop taking Maviret.

Side effects What should I do?
  • Nausea (feeling sick) 
  • Headache
  • Feeling very tired
  • These are quite common when you first start taking Maviret and usually get better with time. Make sure you take your Maviret with food.
  • Tell your doctor if troublesome
  • Signs of an allergic reaction such as skin rash, itching, swelling of the lips, face, and mouth or difficulty breathing
  • Tell your doctor immediately or ring HealthLine 0800 611 116

Learn more

Maviret Medsafe Consumer Information Sheet
Maviret information leaflet Abbvie

References

  1. Maviret datasheet Medsafe, NZ
  2. Glecaprevir + pibrentasvir New Zealand Formulary
  3. Hepatitis C management in primary care has changed BPAC, 2019
Credits: Sandra Ponen, pharmacist. Reviewed By: Angela Lambie, Pharmacist, Auckland; Dr Helen Liley (FRNZCGP), Lead Clinical Editor Auckland Regional HealthPathways Last reviewed: 08 Feb 2019