Glecaprevir and pibrentasvir

Also called Maviret

Easy-to-read medicine information about glecaprevir and pibrentasvir – what it is, how to take glecaprevir and pibrentasvir safely and possible side effects. Glecaprevir and pibrentasvir is also called Maviret®.

Type of medicine Also called
  • Antiviral medicine
  • Medicine to treat chronic hepatitis C  
  • Maviret®

What is Maviret?

Maviret is used to treat chronic hepatitis C, a viral infection of the liver. It works against all types of hepatitis C virus. Maviret is made up of 2 medicines (glecaprevir and pibrentasvir) in a single tablet. 

Dose

  • The dose of Maviret is 3 tablets once daily. 
  • Always take your Maviret exactly as your doctor has told you. The pharmacy label on your medicine will tell you how much Maviret to take, how often to take it, and any special instructions.

How to take Maviret

  • Swallow your Maviret tablets whole with a glass of water.
  • Do not crush, chew or break the tablets.
  • Take your Maviret tablets with food. 
  • Maviret tablets are best taken about the same time each day.
  • If you miss a dose:
    • Within 18 hours, take your missed dose and then continue your regular dosing.
    • More than 18 hours, skip the dose and take the next dose at the usual time.
  • Keep taking your Maviret tablets for the full time it has been prescribed, even if you feel well. 

Precautions – before starting Maviret

  • Are you pregnant or breastfeeding?
  • Have you had hepatitis B infection?
  • Are you taking any other medicines? This includes any medicines you buy without a prescription, such as herbal and complementary medicines?

If so, it’s important that you tell your doctor or pharmacist before you start Maviret. Sometimes a medicine isn’t suitable for a person with certain conditions, or it can only be used with extra care.

Possible side effects

Like all medicines, Maviret can cause side effects, although not everyone gets them. Often side effects improve as your body gets used to the new medicine.

Hepatitis B virus reactivation

Before starting treatment with Maviret, your doctor will do blood tests to check for hepatitis B virus infection. If you have ever had hepatitis B virus infection, the hepatitis B virus could become active again during or after treatment with Maviret. Your doctor will monitor you if you are at risk for hepatitis B virus reactivation during treatment and after you stop taking Maviret.

Side effects What should I do?
  • Nausea (feeling sick) 
  • Headache
  • Feeling very tired
  • These are quite common when you first start taking Maviret and usually get better with time
  • Tell your doctor if troublesome
  • Signs of an allergic reaction such as skin rash, itching, swelling of the lips, face, and mouth or difficulty breathing
  • Tell your doctor immediately or ring HealthLine 0800 611 116

Learn more

Maviret Medsafe Consumer Information Sheet

References

  1. Maviret datasheet Medsafe, NZ
  2. Glecaprevir + pibrentasvir New Zealand Formulary
Credits: Sandra Ponen, pharmacist. Reviewed By: Angela Lambie, Pharmacist, Auckland Last reviewed: 30 Sep 2018